(1) The resulting ester was saponified under basic conditions to the free acid, converted to the acyl chloride with thionyl chloride, and then to the amide with anhydrous ammonia gas.(2) A second component of these molecules was identified as an amide or an amino acid.(3) sodium amide(4) They are intermediates in such reactions as the change of a carboxylic acid to its next highest homologue or to a derivative of a homologous acid such as an ester or an amide .(5) Nitriles are formed by heating amides with phosphorous pentoxide or by treating organic halogen compounds with sodium cyanide.(6) Primary amides are weakly basic and can form compounds with metals such as sodium, potassium, mercury, and cadmium, although heavy metal amides can be explosive.(7) Secondary and tertiary amides are prepared by reacting primary amides or nitriles with organic acids.(8) On the other hand, the permeability of the membrane for small uncharged solutes such as low molecular weight alcohols, amides , ketones etc., did not change.(9) The ester functional group can also be split by ammonia to give amides and alcohols.
