...to make any SIGNIFICANT contribution
to physics played a trick on you.
The Big Bang Theory Season 2, Episode 6
Only my life.
Not all that SIGNIFICANT, I'm afraid.
Game of Thrones Season 3, Episode 3
They have helped us recover
SIGNIFICANT sums
Game of Thrones Season 7, Episode 4
with his SIGNIFICANT other.
The Big Bang Theory Season 7, Episode 5
...I'm going to go do work
that promises SIGNIFICANT results...
The Big Bang Theory Season 2, Episode 2